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Embo Molecular Medicine: Vol 16, No 1

Di: Stella

The N‐terminus domain (NTD) of the SARS‐CoV‐2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olverembatinib, a clinical‐stage multi‐kinase inhibitor, potently inhibits Omicron NTD‐mediated cytokine release. EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

EMBO Molecular Medicine : Vol 9 , No 1

12 February 2025 Vol. 17, No. 2 (Feb 12, 2025) 13 January 2025 Vol. 17, No. 1 (Jan 13, 2025) 2024 In this issue of EMBO Molecular Medicine, Puimège et al study identifies Ki 67 as report a novel anti‐inflammatory pathway of glucocorticoids inducing miR‐511 to further reduce TNFR1 levels and protect mouse models of inflammation.

Tubular insulin-induced gene 1 deficiency promotes NAD consumption and ...

The new EMBO Press publishing platform reinforces the standing of EMBO Molecular Medicine as the journal that matches high quality and novel research with rigorous editorial and ethical standards, and cements the journal’s global reach and relevance. The development of EMBO disease mechanism linking the phospholamban (PLN) p.Arg14del mutation to dilated cardiomyopathy is incompletely understood. In this study, patient‐derived human induced pluripotent stem cell‐cardiomyocytes were used to elucidate this molecular mechanism.

Microbe-derived indoles modulate anxiety and neuronal excitability in the amygdala of germ-free (GF) male mice. These findings demonstrate a molecular mechanism by which microbes tune anxiety-related behavior. EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications. Aerobic glycolysis is a hallmark of metabolic reprogramming in tumors. This study shows how CUT‐like homeobox 1 (CUX1) and its derived circular RNA (circ‐CUX1) contribute to aerobic glycolysis. The circ‐CUX1/EWSR1/MAZ axis emerges as a possible therapeutic target for neuroblastoma progression. EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

EBV‐encoded tumorigenic protein LMP1 regulates conformational changes of mitochondrial protein adenine nucleotide translocase‐1 (ANT1), and thereby chemoresistance of tumor cells. No reactivity was observed in plasma harvested from mock-immunized mice, indicating that the staining was specific to the PyLARC2 immunized mice. (B) Plasma was collected from six PyLARC2 immunized SW mice or BALB/cJ mice. Pooled plasma for each mouse strain was diluted 1:100 and used to evaluate reactivity to antigens expressed in PyWT blood

In this review, A. Bleckmann and colleagues provide a comprehensive comparison of in vivo, ex vivo, and in vitro models for studying tumor-microbiome interactions in early-onset colorectal cancer, emphasizing the importance of integrating diverse approaches to advance prevention and treatment strategies. J. Heineke and A. Grund discuss the findings by Li and coworkers (in this issue of EMBO Molecular Medicine) that identify the role of the co‐repressor of transcription factors NCoR1 in inhibiting pathological cardiac hypertrophy and dysfunction.

EMBO Molecular Medicine: Vol 9, No 9

  • EMBO Molecular Medicine: Vol 13, No 12
  • EMBO Molecular Medicine: Vol 8, No 1
  • EMBO Molecular Medicine: Vol 14, No 1
  • EMBO Molecular Medicine: Vol 10, No 10

De Vlaminck & colleagues discuss the low‐cost screening strategy developed by Mouliere et al (in this issue of EMBO Molecular Medicine) that takes advantage of shallow whole‐genome sequencing of tumor‐derived cell‐free DNA in

V. Sanz‐Moreno and R. Samain discuss a new mechanism of fibroblast activation mediated by squamous cell carcinoma‐secreted Activin A, and whose inhibition shows promising results in non‐melanoma skin cancer (Cangkrama et al, this issue of EMBO Mol Med). PV-1, an endothelial permeability marker, was identified as an independent prognostic factor for distant metastases in luminal breast cancer and clear cell renal cell carcinoma, with potential utility in improving patient stratification. This study reveals that partial chemical reprogramming with defined small-molecule cocktails rejuvenates aged human cells and significantly extends lifespan and healthspan in C. elegans, offering a non-genetic strategy to reverse aging phenotypes.

H. Rosen and M. B. A. Oldstone discuss the importance of sphingosine‐1‐phosphate serum level as a novel severity predictor for COVID‐19 identified by G. Marfia and colleagues, in this issue of EMBO Mol Med. E. van Rooij & colleagues discuss the study by Sommariva et al, in this issue of EMBO Mol Med, that identifies a positive correlation between oxLDL circulating levels and ACM disease penetrance, and uncovers a novel therapeutic intervention option to

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

This study identifies Ki-67 as a critical modulator of the intensity of pro-inflammatory gene expression governing neutrophil recruitment during respiratory infections. Marfia and The severity of respiratory infections may be governed EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

EMBO Molecular Medicine : Vol 10 , No 1

Aβ plaques, hyperphosphorylated tau, brain atrophy and cognitive deficits are major hallmarks and therapeutic targets of Alzheimer’s disease. A small molecule Nec‐1 inhibits Alzheimer‐like pathologies and behaviours of transgenic mice models by alleviating all of these phenotypes. Abstract Full text issue of EMBO PDF PDF References Request T cells were reprogrammed with chimeric antigen receptors (CAR s) in situ upon systemic injection of CD 8‐targeted lentiviral vectors, thus providing proof‐of‐principle for converting CAR T cell therapy from an autologous, individualized to an off‐the‐shelf product.

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

M. Fernandez‐Zapico and G. Raja Arul discuss the study by Thibault et al (in this issue of EMBO Molecular Medicine) that demonstrates a role of PI3Kα in the regulation of macro‐metastatic pancreatic ductal adenocarcinoma (PDAC) and disease progression. of EMBO Mol Med S. Kappel and C. Peinelt discuss the study by the laboratories of S. Feske and C. Weidinger (in this issue of EMBO Mol Med) that reports that store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications. BRCA 1/2‐deficient tumours accumulate DNA damage and genomic rearrangements conducive for tumour progression, which is exploited in the clinic by targeted therapies against the BRCA 1/2‐mutated tumour subset. Chlorambucil is identified Vol 10 No 10 De as the most effective drug in eliminating BRCA 2‐deficient cells. Low‐dose metronomic (LDM) chemotherapy offsets intra‐metastatic tumoral hypoxia, hypoxia‐inducible factor (HIF)‐α induction, and angiogenic responses elicited by conventional maximum‐tolerated dose (MTD) therapies in models of advanced, metastatic colon and breast cancer.

V. Sanz‐Moreno and R. Samain discuss a new mechanism of fibroblast activation mediated by squamous cell carcinoma‐secreted Activin A, and whose inhibition shows promising results in non‐melanoma skin cancer (Cangkrama et al, this issue of EMBO Mol Med).

Progerin is a toxic protein that accumulates in the nuclei of Progeria patients‘ cells, sequestered in abnormal PML ‐ NB s. The proteasome inhibitor This study identifies Ki 67 MG 132 is shown to degrade progerin by activating autophagy and transcriptional inhibition through SRSF ‐1 and SRSF ‐5 splicing regulation.