Humidity Induced Phase Transformation Of Poloxamer 188

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Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical intactness is crucial to the stability of drug products due to its protecting effects at interfaces. In order to identify and Poloxamer 188 enhances survival of red blood cells (RBCs) by increasing the stability and decreasing the fragility of the membrane [2]. Poloxamer 188 arrested the G2/M phase of the cell cycle in the K562 BCR-ABL-mediated CML cell line [3].

Humidity-induced phase transitions of ferric sulfate minerals studied by in situ and ex situ X-ray diffraction Wenqian Xu,1 nicholas J. Tosca,2 scoTT M. Mclennan,1 and John B. Parise1,3,* The suspected reason for this is the very high hydrophilicity of the poloxamer molecule and the strong temperature dependence of the polyethylene oxide content in particular. to prevent protein adsorption to Poloxamer 188 becomes increasingly lipophilic to show micelle formation only at increased temperature or in the presence of specific trehalose concentrations. Request PDF | Role of Poloxamer 188 in Preventing Ice-Surface-Induced Protein Destabilization during Freeze-Thawing | The phase behavior of poloxamer 188 (P188) in aqueous solutions, characterized

Figure1. (a)DSC spectrums of Ropinirole Palmitic Acid Poloxamer 188 ...

The phase behavior of poloxamer 188 (P188) in aqueous solutions, characterized by differential scanning calorimetry (DSC) and synchrotron X-ray diffractometry, revealed solute crystallization during both freezing and thawing.

Amorphous Roxithromycin Loaded in-situ Gel for the Treatment of

Abstract Poloxamer 188 (P188) is a non-ionic amphi-philic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myo-cardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis. P188 is available as an excipient-grade product, Small-molecule preservatives and nonionic surfactants such as poloxamer 188 (P188) are thus often employed in protein drug formulations. However, mixtures of preservatives and surfactants can induce aggregation and even phase separation over time, despite the fact that all components are well dissolvable when used alone in aqueous Publications Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of AMG 579, a PDE10A inhibitor

Share this article Abstract The phase behavior of poloxamer 188 (P188) in aqueous solutions, characterized by differential scanning calorimetry (DSC) and synchrotron X-ray diffractometry, revealed solute crystallization during both freezing and thawing. Sucrose and trehalose inhibited P188 crystallization F 68 during freeze-thawing (FT). Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of AMG 579, a PDE10A inhibitor. International Journal of Pharmaceutics 2017, 521 (1-2) , 1-7. https://doi.org/10.1016/j.ijpharm.2017.01.059

Poloxamer 188, also known as Pluronic F-68, is an excipient added to the biotherapeutic protein-manufacturing process. Poloxamer 188 (P188) is a nonionic triblock copolymer surfactant that can be used as a shear protective excipient in bioreactors. In the current study, a method for the process clearance monitoring of poloxamer 188 during

Poloxamer 188, also known as Pluronic F-68, is an excipient added to the biotherapeutic protein-manufacturing process. Poloxamer 188 (P188) is a nonionic triblock copolymer surfactant that can be used as a shear protective excipient in bioreactors. The molecular properties of poloxamer assemblies and their adsorption properties have been utilized in many applications such as cosmetics and emulsion formulation, effective dispersants for inks/pigments, and versatile anti

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Poloxamer 188 as surfactant in biological formulations
Effect of p 188 concentration on gelation temperature

Effect of Poloxamer 188 (P188) on myocardial inflammation within the ...

Impact of Poloxamer 188 Material Attributes on Proteinaceous Visible Particle Formation in Liquid Monoclonal Antibody Poloxamer 188 (P188) was hypothesized to be a dual functional excipient, (i) a stabilizer in frozen solution to prevent ice-surface-induced protein destabilization and (ii) a bulking agent to provide elegant lyophiles. Based on X-ray diffractometry and differential scanning calorimetry, sucrose, in a concentration-dependent manner, inhibited P188 crystallization

Efficacy of Poloxamer 188 in Carboplatin-Induced Aplastic

Preparation and Characterization of ROX in-situ Gel Poloxamer 407 (F127) and Poloxamer 188 (F68) were dispersed into a PBS solution and stirred at 4°C for 24 hours to achieve a homogeneous solution, with final polymer concentrations of 20.5% (w/w) for F127 and 5.5% (w/w) for F68, respectively. Abstract Poloxamers are negatively temperature-sensitive hydrogels and their hydrophilic groups interact with water molecules at lower temperatures (liquid phase) while their hydrophobic groups interact more strongly with increases in temperature causing gelation. To investigate the factors affecting the rheological properties of poloxamers, various parameters including different

Abstract Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical intactness is crucial to the stability of drug products due to its protecting efects at interfaces. In order to identify and mitigate potential Small-molecule preservatives and nonionic surfactants such as poloxamer 188 (P188) are thus often employed in protein drug formulations. However, mixtures of preservatives and surfactants can induce aggregation and even phase separation over time, despite the fact that all components are well dissolvable when used alone in aqueous solution. Poloxamers for Biopharma: Upstream Cell Culture Applications For more than 50 years, BASF has been producing poloxamer 188 for use in a broad range of applications. Meanwhile, biomanufacturing processes have intensified, so BASF keeps pace with requirements for shear protection by developing the next generation poloxamer 188. Building on the worldwide

Simultaneous analysis of polysorbate 80 and poloxamer 188 in biopharmaceutical formulations using charged aerosol detector and single quadrupole mass spectrometer Xuepu Li 1, Sissi White 2, Mauro De Pra 3, Yu Cui 1, Min Du 2 1Thermo Fisher Scientific, Shanghai, China, 2 Thermo Fisher Scientific, Lexington, MA, US, 3Thermo Fisher Scientific, Germering, Germany Microglia-mediated inflammation contributes to cognitive function impairment. Poloxamer 188 (P188) is an amphipathic polymer which has cytoprotective effect in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced dopaminergic (DA) neurons degeneration in PD. But whether P188 could ameliorate cognitive impairment in PD is

Download Citation | On Feb 1, 2025, Lukas Bollenbach and others published Interfacial and self-association behaviour of poloxamer 188 in aqueous solutions | Find, read and cite all the research Introduction Poloxamer 188 can be used as a non-ionic surfactant in therapeutic formulations to stabilize proteins against mechanical and interfacial stresses, and in mammalian cell culture to protect cells from sheer stress.

Using Bifonazole (BFZ) as a model drug, CSDs were prepared through spray drying with carriers such as Poloxamer 188 (P188), Poloxamer 407 (P407), and polyethylene glycol 8000 (PEG8000). Solid-water interactions should be monitored during the different stages of processing using Process Analytical Technology (PAT) tools or off-line measurements (Raman or Infrared spectroscopy or PXRD) drying with carriers to identify phase transformations in the active. Small-molecule preservatives and nonionic surfactants such as poloxamer 188 (P188) are thus often employed in protein drug formulations. However, mixtures of preservatives and surfactants can induce aggregation and even phase separation over time, despite the fact that all components are well dissolvable when used alone in aqueous

Poloxamer 188: Uses, Interactions, Mechanism of Action

Learn about Poloxamer-188 uses, dosage, side effects, food interactions, and more. Get all the details about Poloxamer-188 from MedicinesFAQ. The results indicated that the stability of poloxamer 188-stabilized emulsions can be influenced in a positive or negative way by the localization of drug molecules in the interface of emulsion droplets. Multi-injection P188 is a non pharmaceutical products such as insulin must be formulated to prevent aggregation and microbial contamination. Small-molecule preservatives and nonionic surfactants such as poloxamer 188 (P188) are thus often employed in protein drug formulations. However, mixtures of preservatives and surfactants can induce aggregation and even phase

Download Table | Properties of poloxamer 188 and Flocork from publication: Causative factors behind poloxamer 188 (Pluronic F68, Flocor™)-induced complement activation in human sera. A In this study, a polymer-stabilized nanoemulsion (PNE) was developed to improve the interact more strongly with inflammatory and analgesic activities of diclofenac (DA). DA-PNEs were prepared from sesame oil and poloxamer 188 (P188), polysorbate 80, and span 80 as emulsifiers and optimized by a systematic multi-objective optimization method. The developed DA-PNEs exhibited

Sci-Hub | Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of AMG 579, a PDE10A inhibitor. International Journal of Pharmaceutics, 521 (1-2), 1–7 | 10.1016/j.ijpharm.2017.01.059 to open science ↓ save ( (btc)) Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of

Download scientific diagram | Effect of p 188 concentration on gelation temperature from publication: Formulation and in vitro evaluation of in situ liquid gelling suppository of promethazine hcl Poloxamer 188, a commonly used emulsifying and solubilizing agent, was found to be the cause of crystallization of an investigational drug, AMG 579, from its amorphous solid dispersion at accelerated storage conditions. Investigation of this physical stability issue included thorough characterization of poloxamer 188 at non-ambient conditions. At 40 degrees C, poloxamer 188

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