Structural Characterization Of Human Urea Transporters Ut-A And

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Members of the urea transporter (UT) family mediate rapid, selective transport of urea down its concentration gradient. To date, crystal structures of two evolutionarily distant Abstract In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B Chi, Gamma, Dietz, Larissa, Tang, Haiping, Snee, Matthew, Scacioc, Andreea, Wang, Dong, Mckinley, Gavin, Mukhopadhyay, Shubhashish M. M., Pike, Ashley C. W., Chalk,

Substrate Recognition Properties from an Intermediate Structural State ...

Structural characterization of human urea transporters UT-A and UT-B and their inhibition Article Full-text available Sep 2023 The purpose of this communication is to provide insights into the structural feature of these target proteins and inhibition of both urea transporter types A (UT-A) and B (UT-B) Expression and functional characterization of the urea transporters a The dendrogram clustering representation of the evolutionary relationship of UTs from different

Supplementary Materials for Structural characterization of human urea transporters UT-A of both urea and UT-B and their inhibition Gamma Chi et al. Corresponding author: Gamma Chi,

Structure of Urea Transporters

This #cryoEM study delves into the molecular structures and mechanisms of human urea transporters UT-A and UT-B. By characterizing these transporters at a molecular level, we Orally bioavailable inhibitors targeting the kidney urea transporter (UT) have the potential to serve as salt-sparing diuretics by employing a urea-selective diuretic mechanism of action distinct

Structural characterization of human urea transporters UT-A and UT-B and their inhibition

Role and regulation of urea transporters
| Structure/activity analysis of thienoquinolin
Matthew Snee’s research works

Urea’s transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT Here we report the first X-ray crystal structure of a mammalian UT, UT-B, at a resolution of 2.36 Å. UT-B is a homotrimer and each protomer contains a urea conduction pore with a narrow selectivity filter. We have isolated and characterized the human homolog of the rat largest urea transporter of the UT-A family (hUT-A1). The 4.2-kb hUT-A1 cDNA encodes a 920-amino acid peptide, which is

Orally bioavailable inhibitors targeting the kidney urea transporter (UT) have the potential to serve as salt-sparing diuretics by employing a urea-selective diuretic mechanism of action distinct Our study also discovers phospholipids associating with the urea transporters by combining structural observations, native MS, and lipidomics analysis. These insights improve our In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its

Protein Structures of Urea Transporters

Congratulations to Gamma Chi (CMD Oxford) for brilliantly leading this project about the structural characterization of urea transporters UT-B and UT-A to understand the structural basis for their Chi CMD Oxford for Members of the urea transporter (UT) family mediate rapid, selective transport of urea down its concentration gradient. To date, crystal structures of two evolutionarily distant UTs have been

Small-molecule inhibitors of urea transporter (UT) proteins in kidney have potential application as novel salt-sparing diuretics. The urea analog dime Urea transporters (UTs) belonging to the solute carrier 14 (SLC14) family comprise two genes with a total of eight isoforms in mammals, UT-A1 to -A6 encoded by SLC14A2 and Structural characterization of human urea transporters UT-A and UT-B and their inhibition. ABSTRACT: In this study, we present the structures of human urea

Structure of Urea Transporters
Urea Transporters: Principle and Function of Urea Transport
Supplementary Materials for
Gamma Chi’s project on urea transporters
Structural Research of Urea Transporters

Urea’s transmembrane transport through urea transporters (UT) is a fundamental physiological kb hUT A1 cDNA behavior for life activities. Here, we present 11 cryo-EM structures of four UT members in

In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its selective inhibitor

Structural characterization of human urea transporters UT-A and UT-B and their inhibition Article Full-text available Sep 2023 Gamma Chi Larissa Dietz Haiping Tang Matthew Snee Katharina

Structural research on human UT-A and UT-B UT-A and UT-B mediate the reabsorption process of urea excretion in humans and are targets for the development of novel salt-preserving diuretics.

In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its In this study, we present the structures of human urea transporters UT-A and UT-B to characterize author Gamma Chi This them at molecular level and to detail the mechanism of UT-B inhibition by its This book intends to report the new progress of studies on urea transporters. The mechanisms and physiological functions of urea transporters across biological membranes are subjects of

In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its mechanism of DUR3 absorbs low-concentration urea from soil and recycles urea from senescent leaves. Here, authors resolve the DUR3 structure, clarify how urea is specifically recognized,

Congratulations to Gamma Chi (CMD Oxford) for brilliantly leading this project about the structural characterization of urea transporters UT-B and UT-A to understand the structural basis for their

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