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The Role Of Lc3B In Autophagy As An Rna-Binding Protein.

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Article “The role of LC3B in autophagy as an RNA-binding protein” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking science and technology information which hitherto stood alone to support the generation of ideas. By linking the information entered, we provide opportunities to make unexpected discoveries and An early event in autophagosome biogenesis involves recruitment of the Vps34/Beclin1 lipid kinase complex to the endoplasmic reticulum (ER) membrane, where it phosphorylates phosphatidylinositol (PI) to form PI3P. 6,7 PI3P then recruits select cytosolic autophagy pathway-initiating proteins, which contain canonical PI3P-binding regions such as Source data are provided as a Source Data file. from publication: LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy | LC3/ATG8 has long been appreciated to play a

Beyond autophagy: the expanding roles of ATG8 proteins

Frontiers | Disrupting the LC3 Interaction Region (LIR) Binding of ...

Medicinal chemists need to follow and understand basic research on the molecular mechanism of autophagy in order to design autophagy-based degraders. Autophagy receptor proteins provide substrate selectivity for degradation. Classically, the model in which receptor proteins tether cargoes to the isolation membrane has been accepted 当前位置: » 论坛 › 科研专区 › 文献互助 › The role of LC3B in autophagy as an RNA-binding prot

Figure 1. Schematic representation of the roles of BIRC6 in regulating autophagy and apoptosis. BIRC6 is a non-canonical, hybrid ubiquitin-conjugating enzyme (E2)-ubiquitin ligase (E3) that, in conjunction with the ubiquitin-activating enzyme (E1) UBA6, mediates ubiquitination and proteasomal degradation of LC3B, thus reducing LC3B-dependent

Here, we uncovered a previously hidden function of the autophagosome component LC3 beyond its role in autophagy by bridging two seemingly unrelated pathways: LFA1 transport and autophagosome Furthermore, we identified PRMT1 mRNA, which encodes a protein that functions as a negative regulator of autophagy, as an LMD substrate. A failure of rapid degradation of PRMT1 mRNA via LMD results in inefficient autophagy. Thus, our study unravels an important role of LC3B in autophagy as an RNA-binding protein for efficient mRNA decay.

Furthermore, we identified PRMT1 mRNA, which encodes a protein that functions as a negative regulator of autophagy, as an LMD substrate. A failure of rapid degradation of as Source data are provided PRMT1 mRNA via LMD results in inefficient autophagy. Thus, our study unravels an important role of LC3B in autophagy as an RNA-binding protein for efficient mRNA decay.

Abstract MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3), a mammalian ortholog of yeast Atg8, is a key protein contributing to major steps of autophagy. It has been recognized for a long time that LC3 is abundant in the nucleus despite the fact that it functions primarily in the cytoplasm where the autophagosomes and autolysosomes arise. An important question

LC3B is an RNA-binding protein with a preference for

For example, Lamin B which interacts with LC3B through a sequence in the N-terminus of LC3B [93]. While ATG8s perform most of their autophagy-related functions once they are conjugated to autophagosome membranes (see below), only a very small number of ATG8 binding partners are known to preferentially bind to this form. Autophagy is that LC3 is abundant a catabolic cellular process in which unwanted proteins and organelles are degraded by lysosomes. It is characterized by the formation of the double-membrane autophagosome decorated with LC3B, a protein that mediates autophagosomal fusion with lysosomes. The cysteine protease ATG4b acts at two stages in the life cycle of LC3B. We

  • Selective Autophagy: RNA Comes from the Vault to
  • The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy
  • Sigma-1 receptor recruits

Binding of GABARAP to ALFY (autophagy-linked FYVE protein) is required for selective binding and the recruitment of ALFY to LC3B-positive structures (36). GABARAP regulates mitophagy via its association with the E3 ubiquitin ligase Mulan, which can Rapid degradation of PRMT1 mRNA by LC3B facilitates autophagy. Collectively, we demonstrate that LC3B acts as an RNA-binding protein and an mRNA decay factor necessary for ef cient autophagy.

The resulting pseudouridylation deficiency directed histone mRNAs to the autophagosome-lysosome pathway, triggering RNA autophagy. This tDR-induced RNA autophagy pathway was activated during murine and human kidney diseases, suggesting clinical relevance. LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited. Here, we show that LC3B is an RNA-binding protein that directly binds to mRNAs with a preference for a consensus AAUAAA Furthermore, we identified PRMT1 mRNA, which encodes a protein that functions as a negative regulator of autophagy, as an LMD substrate. A failure of rapid degradation of PRMT1 mRNA via LMD results in inefficient autophagy. Thus, our study unravels an important role of LC3B in autophagy as an RNA-binding protein for efficient mRNA decay.

Microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein with a molecular mass of approximately 17 kDa that is distributed ubiquitously in mammalian tissues and cultured cells. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organ

Insights into the Mode and Mechanism of Interactions Between RNA and ...

Direct binding of LC3B to mRNAs elicits rapid degradation of target mRNAs. We also observe that the LC3B-mediated rapid decay of PRMT1 mRNA promotes ef cient fi autophagy.

Knupp and Chen et al. have uncovered a role for the ER membrane protein SigmaR1 (S1R) in promoting the localized translation of Atg8 family proteins. S1R directly binds to the 3′ UTR of LC3B mRNA to promote ER-localized translation of the LC3B protein product.

LC3B 作为 RNA 结合蛋白在自噬中的作用,Autophagy

Thus, our study unravels an important role of LC3B in autophagy as an RNA-binding protein for efficient mRNA decay. 中文翻译： LC3B 作为 RNA 结合蛋白在自噬中的作用 Consequently, LC3B elicits rapid degradation of mRNAs, which we have termed as LC3B-mediated mRNA decay 7 PI3P then recruits (LMD). LMD requires the conversion of LC3B-I to LC3B-II and occurs before the formation of autolysosomes. Furthermore, we identified PRMT1 mRNA, which encodes a protein that functions as a negative regulator of autophagy, as an LMD substrate.

A new study shows that the oligomerization of p62/Sequestosome-1 (SQSTM1) — a selective autophagy receptor and signaling adapter — is regulated directly by vault RNA. This riboregulation negatively affects the aggregation state of p62 and thereby its autophagic Lamin B which interacts degradation and its role as a selective autophagy receptor. Source data are provided as a Source Data file. from publication: LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy | LC3/ATG8 has long been appreciated to play a

Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via delivery to lysosomes.

Downloadable! LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited. Here, we show that LC3B is an RNA-binding protein that directly binds to mRNAs with a preference for a Thus, vtRNA1-1 directly regulates selective autophagy by binding p62 and interference molecular mass of approximately 17 with oligomerization, a critical step of p62 function. Our data uncover a striking example of the potential of RNA to control protein functions directly, as previously recognized for protein-protein interactions and post-translational modifications. Role of RNA regulation in autophagy was rather unexplored until Horos et al. recently showed that vault RNA1-1 binds directly to p62/SQSTM1, a well-established autophagy receptor. This binding

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Autophagy is a highly conserved degradation pathway that ensures nutrient recycling and removal of unwanted substrates. This process has a fundamental role in stress adaptation and maintenance of cellular homeostasis. Here, we discuss emerging aspects of the autophagy–RNA interplay, including autophagy-mediated degradation of RNA, RNA-binding 文献 J-GLOBAL ID：202302258637150140 整理番号：23A0925955 RNA結合蛋白質としてのオートファジーにおけるLC3Bの役割【JST・京大機械翻訳】 The role of LC3B in autophagy with LC3B through a as an RNA-binding protein 出版者サイト 複写サービスで全文入手 高度な検索・分析はJDreamⅢで 著者 (3件)： Hwang Supporting: 2, Mentioning: 32 – LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited. Here, we show that LC3B is an RNA-binding protein that directly binds to mRNAs with a

This work showed that the autophagic mechanism of LC3B in the nucleus is a characteristic factor regulating the ciliary differentiation and function of small airway epithelial cells. CQ and IVM were used as inhibitors of this unique autophagy mechanism to confirm the influence of the different roles of LC3B inside and outside the nucleus in subsequent Oxidative-stress enhanced LC3B-II expression but unable to form autophagosomes In cancer microenvironment, autophagy plays the supporting-role for survival by wrapping the unfolded/inactive

亲爱的研友该休息了！由于当前在线用户较少，发布求助请尽量完整的填写文献信息，科研通机器人24小时在线，伴您度过漫漫科研夜！身体可是革命的本钱，早点休息，好梦！ 已完结 标题 The role of LC3B in autophagy as an RNA-binding protein 相关领域 自噬 生物 细胞生物学 信使核糖核酸 核糖核酸 RNA结合