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Tnf-Α Mrna Is Negatively Regulated By Microrna-181A-5P In

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This study hoped to explore the effects and mechanism of long non-coding RNA (lncRNA) LUCAT1 regulating microRNA-181a-5p (miR-181a-5p) on oxidative stress and apoptosis of

Frontiers | Shaping the Innate Immune Response Through Post ...

Adipogenesis is tightly regulated by altering gene expression, and TNF-α is a multifunctional cytokine that plays an important role in regulating lipogenesis. MicroRNAs are

Regulation of chicken Vanin1 gene expression by PPARα and MiRNA-181a-5p

Request PDF | The JAK Inhibitor Tofacitinib Inhibits Structural Damage in Osteoarthritis by Modulating JAK1/TNF-alpha/IL-6 Signaling Through Mir-149-5p | Background However, to date, there are limited studies available investigating the effects of miR-181a-5p and DDX3X on OA, and the question of whether miR-181a-5p regulates the expression of DDX3X

In the present study, we investigated the effects of microRNA-124 (miR-124) on production of the pro-inflammatory cytokine TNF-α in lipopolysaccharide (LPS)-treated mouse MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has Abstract Objective Vanin1 (VNN1) is a pantetheinase that can catalyze the hydrolysis of pantetheine to produce pantothenic acid and cysteamine. Our previous studies showed that

TNF-α mRNA is negatively regulated by microRNA-181a-5p in maturation of dendritic cells induced by high mobility group box-1 protein Article Full-text available Sep 2017

Results: SNHG1 and XIAP were down-regulated, and miR-181a-5p was up-regulated in LPS-induced H9c2 cells. Overexpression of SNHG1 or inhibition of miR-181a-5p facilitated cell The classically activated M1 macrophage is primarily induced by type 1 helper T lymphocyte (Th1)-secreted the precise cytokines, including IFN-γ and tumor necrosis factor-alpha (TNF-α). TNF-α mRNA is negatively regulated by microRNA-181a-5p in maturation of dendritic cells induced by high mobility group box-1 protein. Scientific Reports, 7 (1). doi:10.1038/s41598-017

The potential role of miRNA in regulating macrophage polarization

Furthermore, evaluating putative targets of mmu-miR-181a-5p, we demonstrated this miRNA negatively regulates TNF-α expression following Brucella infection. By contrast, miR-21a-5p The anti-inflammatory efects of miR-181a-5p were evaluated by examining pro-inflammatory The impact of microRNA cytokines (interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α)) in the culture of RPMI MicroRNAs (miRNAs) are a class of small, mature, noncoding RNA that lead to posttranscriptional gene silencing to regulate gene expression. miRNAs are instrumental in

  • miR-369-3p modulates inducible nitric oxide synthase and is
  • miR-146a-5p inhibits TNF-α-induced adipogenesis via
  • MicroRNA-124 negatively regulates LPS-induced TNF-α

Luciferase activity, RNA immunoprecipitation, and chromatin immunoprecipitation assays were employed to validate the binding relationship between miR-181a-5p and Runx1,

Introduction microRNA-181a (miR-181a) is a crucial post-transcriptional regulator of many mRNA transcripts and noncoding-RNAs, influencing cell proliferation, cancer cell Zhu et al. reported that miR-181a-5p regulated the maturation of DCs induced by high mobility group box-1 protein 20. In our recent study, we identified a specific signature of

Generally, miR-181a-5p binds to target RNA sequences with partial complementarity, resulting in suppression of the targeted genes of miR-181a-5p. However, the precise role of miR-181a-5p in Zhu J, Wang FL, Wang HB, et al. TNF-alpha mRNA is negatively regulated by microRNA-181a-5p in matura-tion of dendritic cells induced by high mobility group box-1 protein.

The impact of microRNA-181a-5p and HMGB1 was explored by flow cytometry. Results showed that microRNA-181a-5p was significantly down-regulated by D-GalN/LPS in vivo and in vitro,

RNA splicing regulates the temporal order of TNF-induced gene ...

Sci-Hub | TNF-α mRNA is negatively regulated by microRNA-181a-5p in maturation of dendritic cells induced by high mobility group box-1 protein. Scientific Reports, 7 (1) | 10.1038/s41598

MicroRNA-124 negatively regulates LPS-induced TNF-α

Zhu et al. reported that miR-181a-5p regulated the maturation hydrolysis of pantetheine of DCs induced by high mobility group box-1 protein 20.

TNF-α is a multifunctional cytokine participating in immune disorders, inflammation, and tumor development with regulatory effects on energy metabolism. Our work focused on pattern of some miRNAs namely the Following target prediction and dual-luciferase assay suggested that miR-21-5p played a role by combining with programmed cell death 4 (PDCD4), which was regulated by

Furthermore, evaluating putative targets of mmu-miR-181a-5p, we demonstrated this miRNA negatively regulates TNF-α expression following Brucella infection. By contrast, Here, we first profiled a miRNA microarray of DCs stimulated by HMGB1 and determined that the up-regulated miRNA miR-181a-5p may act as a regulatory miRNA in these Each of these miRNAs, mmu-miR-181a-5p and mmu-miR-21a-5p, could regulate several mRNA targets that could affect the host immune responses to B. abortus (Table S3 in Supplementary Material). mmu-miR-181a-5p was reported to be

Precursor miR-181a/b-1 was over-expressed in cartilage progenitor cells using lentiviral technology Transduced cartilage progenitor cells were cultured as micromass pellets The expression level of miR-181a-5p was lower in lung tissues. miR-181a-5p overexpression alleviated inflammatory response and pathological changes of lung tissues in

Peroxisome proliferator-activated receptor-α (PPARα) and cell apoptosis related molecules were detected by western blot. We demonstrated that CRNDE was markedly down

Real-time PCR was used for assessing the expression pattern of some miRNAs namely let-7b, miR-29a, miR-126, miR-34a, and miR-181a-5p. ELISA was carried out to In vitro, 15d-PGJ 2 inhibited BMM activation via PPARγ. Moreover, miR-27b-3p, miR-181a-1-3p, and miR-326-5p target MIP-1β, TNF-α, and NOS2 mRNA, respectively. The Objective Vanin1 (VNN1) is a pantetheinase that can catalyze the hydrolysis of pantetheine to produce pantothenic acid and cysteamine. Our previous studies showed that

Cellular and Molecular Biology

The anti-inflammatory efects of miR-181a-5p were evaluated by examining pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α)) in the culture of RPMI